The image of the ‘home’ is central to family businesses, beyond its obvious role as the mooring ground for generations of entrepreneurs. Entrepreneurs often find it difficult to keep home and business apart—which is why the story of a home that is itself the business can offer many fascinating lessons. The Biltmore Estate, America’s largest private home and a National Historic Landmark, is today an 8,000-acre, 1,800-employee enterprise, run by a fourth-generation family hand. The estate defies an old myth—that family businesses don’t last beyond three generations. Evolving from just a tourist attraction to a luxury hotel, a winery, a home products line and an equestrian center, Biltmore has been a celebrated model of sustainable growth held together by a strong family anchor over nearly twelve decades. This article explores Biltmore’s mix of family-led and professional management, and how the grand estate is gearing up for the future.