Application Programming Interface (APIs) have increasingly become crucial to digital ecosystems, facilitating interconnectivity and data exchange essential for digital transformation and open innovation in today’s business landscape. In this article, we introduce a perspective on how APIs can be viewed as a means of achieving a dynamic equilibrium between centralization and decentralization for value creation in business ecosystems. Unlike common perspectives that regard APIs solely as technological tools, we examine them as a new way of thinking and organizing and as strategic mechanisms that facilitate both the unbundling and rebundling of business offerings. We also highlight their flexibility in adapting to changing business environments and outline various organizing models ranging from internal coordination to open platforms. This approach enables organizations to dynamically integrate diverse innovative services while maintaining a balance between control and autonomy. Our article draws on insights from open-innovation organizational structures with practical examples from leading edge use and application of APIs, demonstrating the transformative power of APIs on business models and ecosystems. In doing so, we provide a detailed framework and multiple examples, guiding business leaders to strategically incorporate APIs into their offerings.